Cristobal Colon may refer to:

• The Spanish name of the explorer known in English as Christopher Columbus
• Spanish cruiser Cristobal Colon (1887), a Spanish unprotected cruiser that foundered off Cuba in 1895
• Spanish cruiser Cristobal Colon, a Spanish armored cruiser that fought in the Battle of Santiago de Cuba during the Spanish–American War in 1898
• Cristóbal_Colón (F105), a Spanish air defense frigate of the Álvaro de Bazán class.
• Cristóbal, Colón, a port in the Atlantic side of the Panama Canal
• Pico Cristóbal Colón, the highest mountain in Colombia
• Cristóbal Colón Ruiz (born 1954), Puerto Rican politician

Cristóbal is a port town and county in Colón District, Colón Province, Panama with a population of 49,422 as of 2010. It is located on the western edge of Manzanillo Island, on the Atlantic side of the Panama Canal. Cristóbal Colón is the Spanish translation for Christopher Columbus, the Genovese explorer for whom these places were named.

Christopher Columbus (; ; ; ; between 31 October 1450 and 30 October 1451 in Genoa – 20 May 1506 in Valladolid) was an Italian explorer, navigator, colonizer and citizen of the Republic of Genoa. Under the auspices of the Catholic Monarchs of Spain, he completed four voyages across the Atlantic Ocean. Those voyages, and his efforts to establish permanent settlements on the island of Hispaniola, initiated the Spanish colonization of the New World.