Compignano is a village in Italy. It has 175 inhabitants according to the 2001 ISTAT data, who are known as compignanesi. Though a more recent estimate puts the population closer to 177. It is a frazione of the comune of Marsciano, a larger town 12 km away, along strada statale 317 then provinciale 340 to Spina. Compignano is on top of a low (262m) hill, overlooking the valley of the river Nestore, which runs in a wide horseshoe-shaped curve at the foot of the hill.