Brunner's glands (or duodenal glands) are compound tubular submucosal glands found in that portion of the duodenum which is above the hepatopancreatic sphincter (aka sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate) in order to:

• protect the duodenum from the acidic content of chyme (which is introduced into the duodenum from the stomach);
• provide an alkaline condition for the intestinal enzymes to be active, thus enabling absorption to take place;
• lubricate the intestinal walls.