Bloomsbury is an area of the London Borough of Camden, in central London, between Euston Road and Holborn, developed by the Russell family in the 17th and 18th centuries into a fashionable residential area. It is notable for its array of garden squares, literary connections (exemplified by the Bloomsbury Group), and numerous cultural, educational and health-care institutions. Although Bloomsbury was not the first area of London to have acquired a formal square, Bloomsbury Square, laid out in 1660 by Thomas Wriothesley, 4th Earl of Southampton, as Southampton Square was the first square to be named as such.