The Banská Bystrica Region (, ; ) is one of the Slovak regions in the country of Slovakia in Europe. It is the largest of all Slovak regions by area. It was established in 1923; its borders were last adjusted in 1996. Banská Bystrica region consists of 514 municipalities, from which 24 have a status of towns. Administrative center is its seat Banská Bystrica, the largest district town. Other important towns are Zvolen and Brezno.