Antonio Farnese (29 May 1679 – 20 January 1731) was the eighth and final Farnese Duke of Parma and Piacenza. He married, in 1727, Enrichetta d'Este of Modena with the intention of begetting an heir; the marriage, however, was childless, leading to the succession of Charles of Spain–whose mother, Elisabeth Farnese, was Antonio's niece–to the ducal throne.