Afambo is one of the woredas in the Afar Region of Ethiopia. It is named after Lake Afambo, located at the border of this woreda with Asayita, near the international border with Djibouti. Part of the Administrative Zone 1, Afambo is bordered on the south by the Somali Region, on the west by Dubti, on the north by Asayita, and on the east by Djibouti. The largest town in this woreda is Afambo.