An
acid hydrolase (
lysosomal acid lipase) is an
enzyme that works best at acidic
pHs. It is commonly located in
lysosomes, which are acidic on the inside. Acid
hydrolases may be nucleases, proteases, glycosidases, lipases, phosphatases, sulfatases and phospholipases and make up the approximately 50
degradative enzymes of the lysosome that break apart biological matter.