N-Acetylserotonin O-methyltransferase also known as
ASMT is an
enzyme that catalyzes the final reaction in
melatonin biosynthesis, converting
Normelatonin to melatonin. This reaction is embedded in the more general
tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of
5-hydroxy-indoleacetate to 5-methoxy-indoleacetate.