50/50 is a 2011 American comedy-drama film directed by Jonathan Levine, from a screenplay written by Will Reiser, starring Joseph Gordon-Levitt and Seth Rogen, with Anna Kendrick, Bryce Dallas Howard, Serge Houde, Philip Baker Hall, Matt Frewer, and Anjelica Huston in supporting roles. The film is loosely inspired by Reiser's own experience with cancer.